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San Francisco detective Lindsay Boxer calls upon the members of the Women's Murder Club for help when a series of violent incidents puts police on the trail of a killer or killers intent on murdering someone every three days, and the investigation becomes urgent when Boxer learns one of her friends is a target.

Detective Lindsay Boxer calls upon her friends in the Women's Murder Club for help when a series of seemingly unrelated killings jolt the San Francisco area, but the women soon find they are in over their heads, and even worse, have made themselves targets of the murderer.