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When Aphrodite Wigglesmith, a thirteen-year-old, Harvard-educated mathematics genius, returns home to teach remedial math to middle school students, both she and her students end up getting unexpected lessons.

When seventh-grader Jake McQuade mistakes the world's first ingestible knowledge pills for jelly beans, he suddenly knows all about physics and geometry and can speak Swahili (though Spanish would be a lot more useful); but his sort-of girlfriend Grace thinks they can use his new found brilliance to save their middle school from the new principal, who is conspiring to get it shut down.

Twelve-year-old Jake McQuade is the smartest kid in the universe, but if he wants to keep his title he will have to figure out a way to defeat the villain who steals his ingestible knowledge capsules.