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After her overprotective grandmother has a stroke, eleven-year-old Maya, an orphan, leaves her extremely restricted life in California to stay with her mother's family on a remote Wyoming ranch, where she discovers a love of horses and encounters Artemisia, a wild mare that her mother once rode.

When twelve-year-old Elise, orphaned since age three, becomes disheartened by middle school, with its bullies, changing relationships, and higher expectations, keys to long-locked rooms and messages from her late father help her cope.

Will Tuppence's life has always been ruled by science and common sense but in ninth grade, shaken up by the discovery that protons decay, he begins to see the entire world differently and gains new perspective on his relationships with his little sister and two closest friends.

Sixteen-year-old Alex feels so disconnected from his friends that he starts his junior year at a Tuscaloosa, Alabama, high school by attempting suicide, but soon, a friend of his older brother draws him into cross-country running and a new understanding of himself.