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After a kidnapped bank teller uses a neighbor's wandering cat to send an SOS, the FBI assigns a cat-allergic agent to the case.

Queenie is a cat, deeply aware of her own perfection, and Arthur is a dog who normally likes everyone (except Queenie who is devoted to making his life a misery), and they both live at the Blackberry Hill Inn in the Northeast in snow country with their human twins (Harmony and Bro), and Mom; but one winter's day an unpleasant and suspicious stranger comes to stay at the inn, and soon the twin's uncle is framed for murder--and Queenie and Arthur must put aside their differences and work together to solve the mystery and protect their humans.