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Clare Mann, the daughter of a middle-class Protestant family, and Sally Rose, a wealthy Jewish girl, become unlikely friends at Oberlin College in 1973, and form a bond that will sustain them through motherhood, marriage, divorce, and other challenges of life.

Self-doubting Ruth is coddled by her immigrant mother, who uses food to soothe and control.

When Case arrives at her best friend Drea's isolated West Texas home and finds her missing, she embarks on a search for clues about Drea's disappearance while facing the unsettling, cult-like, and possibly murderous behavior of Drea's roommates.