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Ten-year-old orphan twins Wally and Cheyenne Shluffmuffins have a hard time at Cincinnati's Jolly Days orphanage, but things get much worse when the Mandible sisters offer to share their home in the Dripping Fang Forest.

The ten-year-old Shluffmuffins twins, still evading the evil, giant ants that tried to adopt them, discover the culinary delights of swamps and encounter a zombie who bears a strange resemblance to their deceased father.

Twins Wally and Cheyenne Shluffmuffin face giant ants, ghouls, zombies, and a treacherous orphanage matron when they leave their miserable home at Cincinnati's Jolly Days Orphanage to live with the Mandible sisters in the Dripping Fang Forest.

While trying to convince the FBI that giant ants are kidnapping and enslaving the citizens of Cincinnatti, twins Wally and Cheyenne Shluffmuffin, with the help of their vampire father, escape the clutches of the enormous ghouls who want to adopt--and eat--them.

Having been reunited with their zombie father only to have him turn into a vampire after drinking an experimental elixir of life, the ten-year-old Shluffmuffin twins continue to try to elude the giant ants who want to enslave all humans.

When the babies who are being fed on human snot mutate into half-human brats, Hedy Mandible uses her hypnotic control over Cheyenne to force her to teach them proper behavior, while the Jackal initiates another elaborate scheme to assassinate Wally.

Ten-year-old orphan Wally Shluffmuffin engineers a SWAT team-style operation to rescue his twin sister, Cheyenne, from the Mandible sisters; meanwhile, their vampire father's attempts to feed put him in some awkward situations.

Wally & Cheyenne Shluffmuffin are back to the clutches of the show-tune happy Hortense Jolly at the Jolly Days Orphanage where another odd adventure ensues.