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Filled with resentment over the attention showered upon her twin sister, and awaiting the day she can leave her town behind, young Louise meets a wise old sea captain and begins learning how to let go of her anger.

Thirteen-year-old fraternal twins Dallas and Florida have grown up in a terrible orphanage, but their lives change forever when an eccentric but sweet older couple invites them each on an adventure, beginning in an almost magical place called Ruby Holler.

While working at pleasant but mundane summer jobs in San Francisco, fifteen-year-old twins, Sophie and Josh, suddenly find themselves caught up in the deadly, centuries-old struggle between rival alchemists, Nicholas Flamel and John Dee, over the possession of an ancient and powerful book holding the secret formulas for alchemy and everlasting life.

Twins Jake and Lily have a very close relationship, but when they turn eleven, their parents give them separate bedrooms and Jake begins to spend time with a group of neighborhood boys.