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Runaways Axi, sixteen, and Robinson, seventeen, who met on a cancer ward, leave small-town Oregon on a cross-country trip to experience the best of life before it is too late.

Seventeen-year-old Steven "Stiggy" Gabel tries to cope with his father's suicide, his mother's depression, and his girlfriend's departure by taking off down the Great River Road from Minnesota to Louisiana.

Eighteen-year-old Bea runs from her small-town Texas home and meets Lou, who is taking a road trip to cope with the grief of losing her mother.