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Tenma, in searching for information about the 511 Kinderheim orphanage, and Johan's twin sister Anna, who wants to stop her brother herself, are both led by their investigations to a powerful neo-Nazi organization that conspires to establish Johan as their new superleader.

Dr. Kenzo Tenma, a brilliant Japanese surgeon working in a German hospital, disobeys orders to operate on the mayor in order to save the life of a young boy, and lives to regret his decision when the child grows up to be a killer.