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The twins investigate when their dog Clue is framed for the disappearance of Fiona O'Leary's cat.

As Halloween approaches, twins Mary-Kate and Ashley investigate when Lucy, a black tattooed cat rumored to have the power to grant wishes, disappears.

Queenie is a cat, deeply aware of her own perfection, and Arthur is a dog who normally likes everyone (except Queenie who is devoted to making his life a misery), and they both live at the Blackberry Hill Inn in the Northeast in snow country with their human twins (Harmony and Bro), and Mom; but one winter's day an unpleasant and suspicious stranger comes to stay at the inn, and soon the twin's uncle is framed for murder--and Queenie and Arthur must put aside their differences and work together to solve the mystery and protect their humans.

"Queenie the cat has a BIG problem. And for once, it's not the slobbery, overly-excited creature who also lives at Blackberry Hill Inn.