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The Baker Street Irregulars return to help Sherlock Holmes with a strange mystery involving murder, abduction, and a search for lost treasure, and when a personal friend of Holmes disappears, the gang tries to determine whether there is a traitor in their ranks.

The ragtag group of orphan boys known as the Baker Street Irregulars faces shady characters and seemingly real ghosts when they assist the famous detective, Sherlock Holmes, in investigating the mysterious death of Greta Berlinger during a s?ance.