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After her overprotective grandmother has a stroke, eleven-year-old Maya, an orphan, leaves her extremely restricted life in California to stay with her mother's family on a remote Wyoming ranch, where she discovers a love of horses and encounters Artemisia, a wild mare that her mother once rode.

When twelve-year-old Elise, orphaned since age three, becomes disheartened by middle school, with its bullies, changing relationships, and higher expectations, keys to long-locked rooms and messages from her late father help her cope.

Will Tuppence's life has always been ruled by science and common sense but in ninth grade, shaken up by the discovery that protons decay, he begins to see the entire world differently and gains new perspective on his relationships with his little sister and two closest friends.

Zoe's sixth-grade year at a Brooklyn school for gifted students is marked by changing relationships with her fellow students and teachers, recognition of her talent for cryptography, and a greater awareness of her passion.

When she is abandoned by her alcoholic mother, high school senior Ruby winds up living with Cora, the sister she has not seen for ten years, and learns about Cora's new life, what makes a family, how to allow people to help her when she needs it, and that she too has something to offer others.

Sixteen-year-old Alex feels so disconnected from his friends that he starts his junior year at a Tuscaloosa, Alabama, high school by attempting suicide, but soon, a friend of his older brother draws him into cross-country running and a new understanding of himself.

When her father is injured, fourteen-year-old Nazia is pulled away from school, her friends, and her preparations for an arranged marriage, to help her mother clean houses in a wealthy part of Karachi, Pakistan, where she finally rebels against the destiny that is planned for her.

Sky Brightman, living happily off the grid on sixty acres in New Mexico, with no television or Internet to bring her news of the war going on in the United States, is forced to face reality when her friend Kareem is unjustly arrested.

"Sixteen-year-old San Franciscan Lucy Beck-Moreau once had a promising future as a concert pianist.

Thirteen-year-old Olivia Hughes is forced to rethink her plans to become an actress when a full-blown case of acne results in the dramatic decline of her popularity at school, and the cancellation of a national advertising campaign.

When she is abandoned by her alcoholic mother, high school senior Ruby winds up living with her sister Cora, whom she has not seen for ten years, where she learns about Cora's new life, what makes a family, how to allow people to help her when she needs it, and that she has something to offer to others as well.

Evan and Lucy, childhood best friends who grew apart after years of seeing one another only during Christmas break, begin a romance at age seventeen but his choice to mindlessly follow his father's plans for an Ivy League education rather than becoming the cartoonist he longs to be, and her more destructive choices in the wake of family problems, pull them apart.

Upon learning that her deceased mother, an artist, went through a "Purple Period," ten-year-old Noonie decides to do the same, hoping that this will bring her archaeologist father home to see her win a school art contest and that the aunt, uncle, and cousin she lives with will come to understand her just a little.

A claustrophobic boy dreams of going to college and becoming a newspaperman rather than a miner like his father, but when all union miners in the Coeur d'Alene Mining District are arrested, Mick develops new respect for his father while taking over responsibility for his family.

Isolated from friends who believe the worst because she has not been truthful with them, sixteen-year-old Annabel finds an ally in classmate Owen, whose honesty and passion for music help her to face and share what really happened at the end-of-the-year party that changed her life.