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While running a spy network from their elementary school, five unpopular misfits combine their talents and use cutting-edge gadgetry to fight evil around the world.

When Ms. Information kidnaps the President's daughter, it is up to twelve-year-old Ruby, also known as Pufferfish, to use her super-nanobyte-enhanced allergies in leading the NERDS' investigation.

Led by Duncan "Gluestick" Dewey, the NERDS team uses brain power and courage rather than gadgets when they face off against supervillain Simon, his band of savage squirrels, and Albert, a middle-aged computer genius who lives with his mother.

Former NERDS teammate Heathcliff Hodges introduces a virus to Arlington, Virginia, home of the NERDS headquarters, and it transforms people into superintelligent criminal masterminds.

Led by Duncan "Gluestick" Dewey, the NERDS team uses brain power and courage rather than gadgets when they face off against supervillian Simon, his band of savage squirrels, and Albert, a middle-aged computer genius who lives with his mother.